In November 2023 the SIN List was updated with four new CAS numbers, two of which were added to the Candidate List earlier in 2023, and two additional CAS numbers related to substances already on the SIN List.
The SIN List was first launched in 2008. At this time there were not yet any substances on the official candidate list. The SIN List was created to illustrate which concrete substances that were expected to be covered by the REACH regulation. This was also before the first round of REACH registrations. Three categories of substances were added:
- Officially classified CMR (carcinogenic, mutagenic and reprotoxic) substances, by default fulfilling REACH SVHC criteria, and for which a non-intermediate use could be expected.
- PBT (persistent, bioaccumulative and toxic) and vPvB (very persistent and very bioaccumulative) substances which had been identified by the EU PBT working group.
- Substances of Equivalent Level of Concern were added after careful scientific reviews. Decision of inclusion was taken based on the full hazardous profile of the chemical (often several endpoints).
In 2009 a minor update was made following that more substances had received CLP classification corresponding to SVHC criteria.
In 2011 an update was made, entirely focusing on endocrine disrupting chemicals (EDCs). The aim of the update was to show that endocrine disrupting chemicals are relevant for the candidate list and can be identified on a case-by-case update, even in the absence of criteria. 22 EDCs were identified based on thorough scientific reviews.
The update in 2013 used the newly available information from the registration dossiers to identify classified substances that had earlier been exempted from the SIN List, as they were expected to be used only as intermediates. The full registration of these substances indicated instead also a non-intermediate use.
In 2014 the SIN List was updated with further PBT and EDC substances after thorough scientific reviews. The substances on the SIN List, new and existing, were also grouped based on their toxicological properties and molecular structure.
In September 2015 a minor update was made in the SIN List, together with the launch of the new SINimilarity tool. Substances that had recently been officially recognised as fulfilling REACH criteria, either by new CLP classification (3 substances) or by candidate listing (4 substances) were added to the SIN List. A number of CMR classified substances from the petroleum group which had earlier been excluded from the SIN List but just recently been fully registered (indicating non-intermediate use) were also added (7 substances).
In April 2016, The SIN List and SIN Producers have got new background data and 18 new SVHC substances were added, making the new total number of substances 862 on the SIN List. The new substances originates mainly from ChemSec having added CAS numbers for some groups (alkylphenol and their etoxilates). These are one entry on the candidate list, but consist of several CAS. We have also added a few substances which were SVHC identified in December and which was not already on SIN.
In July 2016, information about chemical companies producing SIN substances in the USA was added, both to the SIN List and the SIN Producers List. This information is based on the US EPA registry data.
In October 2016 a new filtering option was added. It is now possible to filter the list to only show SIN substances related to food contact materials.
In February 2017 the SIN List was updated with 50 new substances. 30 of those were included in the candidate list in January. The new substances originates from ChemSec having added CAS numbers for the newly agreed group of heptylphenols. This is one entry on the candidate list, but consist of several CAS numbers. Chemsec also added a few more CAS numbers to existing entries (two salts of PFDA and three varieties of octylphenol etoxilates). This information originates from the supporting documents for each substance placed on the REACH candidate list.
In addition to these substances we have also included 20 newly classified substances (CMR category 1A or 1B) from ATP09 and a coming ATP10 and included them as well in the SIN List.
In October 2017, The SIN List and SIN Producers List were updated with new background information about chemical companies producing SIN substances in the EU and US. This information is based on REACH registrations from the ECHA databases (based on 2017 data) and US EPA Chemical Data Reporting (CDR) information (based on 2016 data).
In February 2018 The SIN List was updated with a few CAS numbers to reflect the update of the REACH Candidate List and the supporting documentation of the newly added substances. Two new CAS numbers were added to the entry Dechlorane+. In addtion one new substance, not having any CAS number on the Candidate List was added and the CAS and EC numbers from its supporting document was used.
In June 2018 The SIN List was updated with six CAS numbers to reflect the update of the REACH Candidate List.
In January 2019 further 5 CAS numbers were added to the SIN Llst. This as a result of new SVHCs being adopted for the Candidate List. The new CAS numbers, represents three new entries on the Candidate List: fluoranthene (CAS 206-44-0, 93951-69-0), phenanthrene (CAS 85-01-0) and pyrene (CAS 129-00-0, 1718-52-1). All these three entries are in fact constituents of coal-tar pitch high-temperature (CTPHT, CAS 65996-93-2), which was added to the SIN List (and Candidate List) in 2009.
In August 2019 the SIN List was updated with 9 new CAS numbers. This as a result of two new SVHC entries to the REACH Candidate List. Five of the CAS numbers relate to different salts of the PFAS substance called HFPO-DA or GenX. In addition, four CAS numbers relating to tris(nonylphenol) phosphite and related salts were added – when containing more than 0.1% of 4-nonylphenol.
In November 2019 the SIN List was updated with 60 CAS numbers. 29 of those are Persistent, Mobile and Toxic (PMT), or very Persistent and very Mobile (vPvM) compounds. 16 are Persistent, Bioaccumulative and Toxic (PBT), or very Persistent and very Bioaccumulative (vPvB). These chemicals were added by ChemSec after having performed scientific evaluations against the REACH PBT/vPvB criteria and the PMT/vPvM criteria proposed by the German Environment Agency UBA in 2019. Also the first nanomaterial has now been included on the SIN list, Carbon nanotubes with one CAS number.
In addition, 14 substances, having been officially agreed to be classified as Carcinogenic, Mutagenic or Toxic to reproduction since the last SIN List update were also added.
In January 2021 the SIN List was updated with 6 new CAS numbers. This followed on an agreed harmonized classification of a number of substances in ATP15. Three of these new SIN substances were also agreed as SVHCs by the ECHA Member State Committee and included in the REACH Candidate List.
One substance was removed from the SIN List (for the first time), due to us noticing an earlier mistake building on an error in the official classification documentation. A substance classified as suspected to be Toxic to Reproduction (Repr. 2) had in the EU Official Journal been labelled as Repr. 1B. This is now corrected and the substance is removed from the SIN List (CAS# 170016-25-8; EC#427-050-1).
In March 2021 a login function was added to the SIN List. This was done to get to know the users of the SIN List better and for ChemSec to able to provide more features in the future as the SIN List expands. Searching the SIN List is still free-of-charge, the only thing that has changed is that searching it requires registration.
In September 2021 the SIN List was updated with in total 31 CAS numbers, representing 6 new entries, that had been added to the REACH Candidate List. Three of the entries are toxic to reproduction, one is PBT/vPvB, one is carcinogen and one is a respiratory sensitizer.
In February 2022 the SIN List was updated with three new substances following the update of the REACH Candidate List.
In February 2023, an additional 370 PFAS chemicals were added to the SIN List. These substances were added based on the fact that they are registered for being produced or imported to the EU or the US.
You can find more details on how this was done here. In addition to these PFAS, two substances were added following the recent Candidate List update. These two substances were Barium diboron tetraoxide and Isobutylparaben.
SIN List materials
Click here to find all the publications related to the SIN List.